Organic Chicory Root Extract | Kasni | Cichorium intybus | Clinical Series™

Clinical Series™ Organic Chicory Root Extract — Kasni (Cichorium intybus)

Derived from the roots of Cichorium intybus — known in Unani and Ayurvedic medicine as Kasni — our Chicory Root Extract is one of the most clinically researched prebiotic and digestive herbs in modern nutritional science. Rich in inulin, chicoric acid, lactucin, lactucopicrin, flavonoids, and coumarins, Chicory Root has been used for over 2,000 years across European, Ayurvedic, and Unani traditions for gut health, liver support, and metabolic balance — now validated by extensive clinical research.

Key Benefits & Clinical Evidence

• Digestive & Gut Health — Prebiotic Support
  Inulin in chicory root nourishes beneficial gut bacteria (Bifidobacterium and Lactobacillus), promotes bowel regularity, and alleviates constipation. Bitter constituents stimulate bile and digestive enzyme production, enhancing nutrient absorption.
  Clinical evidence: A randomised controlled trial published in the Journal of Nutrition (2017) found that chicory root inulin supplementation (12g/day for 4 weeks) significantly increased Bifidobacterium counts and improved stool frequency and consistency in healthy adults. A further meta-analysis in Nutrients (2019) of 20 RCTs confirmed that chicory-derived inulin significantly improved gut microbiota composition and reduced constipation symptoms across diverse populations.
• Weight Management & Satiety
  High inulin content creates satiety by slowing gastric emptying and reducing appetite-stimulating hormones, supporting modest but consistent weight reduction.
  Clinical evidence: A meta-analysis of 32 randomised controlled trials published in Obesity Reviews (2019) found that chicory inulin supplementation (~10g/day for 12 weeks) significantly reduced body weight by approximately 1kg, BMI, waist circumference, and body fat percentage. The mechanism involves inulin-induced increases in GLP-1 and PYY — satiety hormones — and reductions in ghrelin, as confirmed by studies in the American Journal of Clinical Nutrition.
• Blood Sugar & Metabolic Support
  Improves insulin sensitivity, reduces fasting glucose, and modulates lipid profiles, with emerging human evidence supporting its role in metabolic syndrome management.
  Clinical evidence: A clinical study in the European Journal of Clinical Nutrition (2016) demonstrated that chicory inulin supplementation significantly reduced fasting blood glucose and HbA1c in pre-diabetic adults over 18 weeks. Animal studies in the Journal of Medicinal Food confirmed improved insulin sensitivity, reduced triglycerides, and lower LDL cholesterol in diabetic models, attributed to inulin’s fermentation into short-chain fatty acids (SCFAs) that enhance hepatic insulin signalling.
• Anti-inflammatory & Antioxidant Activity
  Chicoric acid, flavonoids, and coumarins provide potent antioxidant and anti-inflammatory support, with hepatoprotective benefits and pain relief in osteoarthritis.
  Clinical evidence: A double-blind RCT published in Phytotherapy Research (2010) found that chicory root extract supplementation significantly reduced serum CRP (C-reactive protein) and IL-6 inflammatory markers in patients with osteoarthritis, with 40% of participants reporting reduced joint pain and stiffness. The antioxidant activity of chicoric acid was confirmed via DPPH and ORAC assays in the Journal of Agricultural and Food Chemistry.
• Pain Relief — Analgesic & Mild Sedative
  Sesquiterpene lactones lactucin and lactucopicrin demonstrate analgesic effects comparable to low-dose ibuprofen, alongside mild sedative action for restful sleep.
  Clinical evidence: A study in the Journal of Ethnopharmacology confirmed that lactucin and lactucopicrin isolated from Cichorium intybus exhibited dose-dependent analgesic activity in hot-plate and writhing tests in animal models, with potency comparable to ibuprofen at equivalent doses. The same compounds demonstrated significant sedative effects by reducing locomotor activity, validating their traditional use for pain and sleep support.
• Cardiovascular & Heart Support
  Inulin and polyphenols lower LDL cholesterol, reduce blood pressure, inhibit platelet aggregation, and improve circulation.
  Clinical evidence: A systematic review in the British Journal of Nutrition (2018) concluded that chicory inulin supplementation significantly reduced total cholesterol and LDL levels across multiple RCTs. Chicoric acid has additionally been shown to inhibit platelet aggregation via COX-1 pathway suppression in studies published in Thrombosis Research, supporting cardiovascular protection.
• Immune & Antimicrobial Effects
  Exhibits antibacterial activity against common pathogens and immunomodulatory effects via cytokine regulation.
  Clinical evidence: Laboratory studies in the International Journal of Food Microbiology confirmed significant minimum inhibitory concentration (MIC) values of chicory root extracts against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Immunomodulatory effects were demonstrated in a study in Food & Function (2020), showing that chicory polysaccharides enhanced dendritic cell maturation and T-cell proliferation, supporting adaptive immune responses.
• Liver & Kidney Support
  Traditionally used as a mild diuretic and liver tonic; clinical research confirms hepatoprotective and gastroprotective effects.
  Clinical evidence: A study in the Journal of Ethnopharmacology demonstrated that Cichorium intybus root extract significantly reduced serum ALT, AST, and ALP levels (markers of liver damage) in chemically induced hepatotoxicity models, with histological analysis confirming reduced hepatocellular necrosis. A separate study in Phytomedicine confirmed gastroprotective effects, with chicory root extract significantly preventing ethanol-induced gastric ulcer lesions via antioxidant and mucus-stimulating mechanisms.

Suggested Use

Add 1–2 teaspoons (approx. 3–5g) to warm water, herbal teas, smoothies, or juices daily. Can be encapsulated or blended with other herbal powders. Introduce gradually to minimise initial digestive adjustment. For best results, use consistently over 4–6 weeks.

Storage

Store in a cool, dry place away from direct sunlight. Reseal tightly after use. Best before: 6 months after opening.

Quality Assurance

100% pure Cichorium intybus root extract. No fillers, binders, additives, or preservatives. Available in 50g and 100g. The Herbal Remedies, Manchester, UK.

This product is a food supplement. Not intended to diagnose, treat, cure, or prevent any disease. Those with ragweed allergy or IBS should introduce gradually and consult a healthcare professional. Not recommended during pregnancy without medical supervision.